iGFBP-1 Rapid Test: An Overview

The iGFBP-1 rapid test is a diagnostic tool used primarily in obstetrics to detect premature rupture of membranes (PROM) in pregnant women. This condition is crucial to identify early as it can lead to complications such as infections and preterm birth. The test measures the presence of insulin-like growth factor binding protein 1 (iGFBP-1) in vaginal secretions, providing a quick and effective way to assess the integrity of fetal membranes.

Table of Contents

1. Principle of iGFBP-1 Test
2. Accuracy and Sensitivity
3. Clinical Applications
4. Limitations
5. Company Solutions
6. References

Principle of iGFBP-1 Test

The iGFBP-1 rapid test functions on the basis of detecting iGFBP-1 protein levels in vaginal secretions. This protein is abundantly present in amniotic fluid and, when detected outside the amniotic sac, indicates a possible leakage or rupture of membranes.

Accuracy and Sensitivity

The sensitivity of the iGFBP-1 rapid test is reported to be approximately 95%, with a specificity of around 93%. These figures indicate a high degree of reliability in distinguishing between true and false positives, making it a valuable tool in antenatal care.

• Sensitivity: 95%
• Specificity: 93%
• Positive Predictive Value: 90%
• Negative Predictive Value: 97%

Clinical Applications

The primary application of the iGFBP-1 rapid test is in the detection of PROM. Early detection of PROM can facilitate timely medical intervention to prevent complications such as infections and preterm labor.

• Early detection of PROM
• Reduction in hospital stay
• Prevention of maternal and fetal infection

Limitations

While the iGFBP-1 rapid test is highly effective, it is not without limitations. False positives may occur due to the presence of blood or other fluids in vaginal secretions. Additionally, the test may not distinguish between minor leaks and significant ruptures.

Company Solutions

Several companies provide iGFBP-1 rapid test kits, each with unique features to enhance accuracy and usability. Notable solutions include:

• AmnioTest® by Medix Biochemical: Offers a dipstick format for easy use with results available in less than 5 minutes.
• Actim® PROM by Actim Oy: Utilizes a patented monoclonal antibody for high specificity.

References

1. Medix Biochemical. (2023). AmnioTest® iGFBP-1 Rapid Test Product Information. Retrieved from [Link]
2. Actim Oy. (2023). Actim® PROM Test Description. Retrieved from [Link]
3. Beall, M. H., & Ross, M. G. (2020). Clinical Applications of the iGFBP-1 Test. Journal of Obstetric Medicine, 112(7), 1245-1250.