Table of Contents

1. Introduction to Sepsis
2. Common Biomarkers for Diagnosing Sepsis
3. Joinstar Company Solutions
4. Conclusion
5. References

Introduction to Sepsis

Sepsis is a life-threatening condition that arises when the body's response to infection causes injury to its tissues and organs. Rapid identification and diagnosis are crucial to improving patient outcomes. Biomarkers play a vital role in the early detection and management of sepsis.

Common Biomarkers for Diagnosing Sepsis

Biomarkers are measurable substances in an organism whose presence indicates some phenomenon such as disease, infection, or environmental exposure. In the context of sepsis, several biomarkers have been identified to aid in diagnosis and prognosis:

C-reactive Protein (CRP)

CRP is a protein that increases in the blood with inflammation and infection. It is commonly used in clinical settings as a non-specific marker of inflammation. Normal ranges are typically below 10 mg/L, with levels rising significantly during sepsis.

Procalcitonin (PCT)

PCT is a precursor of the hormone calcitonin and is more specific to bacterial infections. It can be an early biomarker for sepsis, with levels greater than 0.5 ng/mL suggesting a systemic bacterial infection.

Interleukin-6 (IL-6)

IL-6 is a cytokine involved in the inflammatory response. Elevated levels are observed in sepsis, and IL-6 can be used to assess the severity of the condition. Values above 50 pg/mL are indicative of an inflammatory process consistent with sepsis.

Lactate

Increased blood lactate levels are indicative of tissue hypoperfusion and can be used as a marker for sepsis severity. Levels above 2 mmol/L are associated with higher mortality in septic patients.

White Blood Cell Count (WBC)

An elevated or low WBC can indicate an infection. Normal ranges vary, but a count of more than 12,000 cells/mm³ or less than 4,000 cells/mm³ is suspected in sepsis.

Joinstar Company Solutions

Joinstar, a leading company in diagnostic solutions, offers innovative technologies for sepsis detection. Their portfolio includes:

Joinstar CRP Test

Joinstar provides a rapid CRP test that delivers results in less than 15 minutes, allowing for timely decision-making in clinical settings.

Joinstar Procalcitonin Assay

This assay is designed for the specific detection of PCT and provides results to aid in the diagnosis of bacterial infections and sepsis management.

Joinstar IL-6 Monitoring

With advanced sensitivity, Joinstar's IL-6 test offers reliable measurements to help assess inflammation levels in septic patients.

Lactate Meter

Joinstar's portable lactate meter enables the quick assessment of lactate levels, crucial for monitoring the severity of sepsis.

Conclusion

Sepsis requires swift and accurate diagnosis to reduce mortality rates. The use of biomarkers such as CRP, PCT, IL-6, lactate, and WBC is integral to this process. Joinstar's solutions provide healthcare professionals with the tools needed for effective management of sepsis.

References

1. Levy MM et al. The Surviving Sepsis Campaign. Intensive Care Med. 2010.
2. Schuetz P et al. Procalcitonin for diagnosis of infection and guide to antibiotic decisions. J Infect. 2017.
3. Simon L et al. Review: Interleukin-6 and Procalcitonin as Biomarkers of Sepsis. Crit Care Med. 2004.
4. Joinstar. Innovative Diagnostic Solutions. Joinstar official website.