Table of Contents

1. Introduction
2. Accuracy of the Dengue NS1 Antigen Test
3. Key Performance Metrics
4. HYSEN Company Solutions
5. References

Introduction

The Dengue NS1 antigen test is a rapid diagnostic tool used for the early detection of dengue fever. It plays a critical role in identifying dengue virus infection in patients during the acute phase, when the presence of the NS1 protein is most detectable.

Accuracy of the Dengue NS1 Antigen Test

The diagnostic accuracy of the Dengue NS1 antigen test is determined by several parameters, including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). These parameters are essential in assessing the test's efficacy under various clinical settings.

Sensitivity and Specificity:

• Sensitivity: Typically ranges between 70% to 90% in detecting NS1 antigen in the first 1 to 3 days of symptom onset.
• Specificity: Can achieve levels above 95%, indicating a high probability of true negative results.

Positive and Negative Predictive Values:

• Positive Predictive Value (PPV): Varies depending on the prevalence of dengue in the tested population but can range from 80% to 95% in high prevalence scenarios.
• Negative Predictive Value (NPV): Also depends on prevalence and typically exceeds 80% when prevalence is high.

Key Performance Metrics

Performance metrics provide insight into the test's reliability across various populations and epidemiological conditions. The following metrics highlight the capabilities and limitations of the NS1 test:

• Early Detection Capacity: The NS1 antigen test can identify the infection within the early phases, particularly 1-3 days post-infection, crucial for timely intervention.
• Cross-Reactivity: Minimal cross-reactivity with other flaviviruses. However, careful consideration is advised in regions where multiple flaviviruses are endemic.
• Usability: Simple to administer with results available typically within 15-30 minutes, rendering it suitable for point-of-care testing.

HYSEN Company Solutions

HYSEN has developed a suite of high-performance solutions aimed at enhancing the detection accuracy of the dengue NS1 antigen. Their products feature:

• Advanced Assay Technology: Utilizing the latest advancements in immunoassay technology to improve sensitivity and specificity.
• Comprehensive Diagnostics: Offering kits that integrate with other diagnostic measures to provide a holistic view of patient health.
• Field Adaptability: Designed for ease of use in diverse environments, ensuring reliability in both urban and rural settings.

References

1. World Health Organization. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control.
2. Centers for Disease Control and Prevention. Dengue Virus: Importance and Use of Laboratory Diagnosis.
3. HYSEN Company, Dengue NS1 Antigen Test Kit Specifications and Performance Data.